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Regulation of PFK-1 The effect of ATP on the allosteric enzyme PFK-1 is shown below. For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but a point is reached beyond which increasing the concentration of ATP inhibits the enzyme. (a) Explain how ATP can be both a substrate and an inhibitor of PFK-1. How is the enzyme regulated by ATP? (b) In what ways is glycolysis regulated by ATP levels? (c) The inhibition of PFK-1 by ATP is di
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SOLVED: Select the true statements about the PFK-] reaction.In heart tissue, the PFK-1 products are more abundant than reactants The PFK-] reaction in heart tissue does not reach equilibrium: Under standard conditions, the PFK-I reaction reaches equilibrium when the concentrations of all products and reactants are equal: In heart tissue, the PFK-] reaction will be driven toward product formation
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