The first type II topoisomerase to be discovered was DNA gyrase from bacteria, by Martin Gellert and coworkers in 1976, [5] and also characterized by Nicholas Cozzarelli and co-workers. [6] DNA gyrase …

Feb 27, 2023 · What is Topoisomerase? Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination.

Jun 2, 2024 · Topoisomerase is a broad class of enzymes that includes various types, such as topoisomerase I and topoisomerase II. It is a large class of enzymes involved in maintaining the …

Jul 31, 2025 · Topoisomerase is an enzyme that manages the complex structure of DNA in all living cells. These enzymes control the topological state of DNA, which refers to how DNA strands are …

DNA topoisomerase VIII (topo VIII), discovered in 2014, is a novel member of the topo family. Identified through database screening using S. shibatae Top6B, topo VIII was classified as a highly divergent …

Protein complexes that track along DNA, such as transcription or replication complexes, produce alterations in DNA supercoiling that are regulated by ubiquitous topoisomerase enzymes.1 The …

DNA topoisomerases are essential enzymes that govern DNA topology during fundamental nuclear metabolic processes. Topoisomerase-interfering compounds can be divided into two general …

Topoisomerase is a class of enzymes that play a crucial role in DNA metabolism and regulate the topological state of DNA.

Nov 25, 2023 · What is DNA Topoisomerase. How does it work. What do they do. Learn their types and structure with a diagram.

In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly all the known classes of enzymes, have been solved. These structures provide remarkable insights into …