Histone chaperones also participate in the selective deposition of histone variants, which are functionally distinct from canonical histones. For example, HIRA is a chaperone that specifically deposits the …

A histone is a type of protein that plays a critical role in the structural organization and regulation of DNA within the nucleus of eukaryotic cells.

2 days ago · Histone. Eight histone proteins can come together to make up something called a nucleosome. A nucleosome is like a tiny spool that DNA can wind around. So histones play an …

Aug 22, 2025 · When DNA is damaged, histone modifications can help make affected DNA regions more accessible to repair enzymes. For example, specific histone modifications can recruit repair …

A protein that is part of the histone family of basic proteins which associate with DNA in the nucleus and help to condense the DNA into a smaller volume.

Histone modifications have been implicated in maintaining the transcriptionally poised state of important genesin embryonic stem cells. Histone modifications are believed to be responsible for …

histone (HIS-tone) A type of protein found in chromosomes. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes.

Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.

Histone was first discovered by Albrecht Kossel in 1884 [1]. Histones are a family of alkaline proteins found in the nuclei of eukaryotic cells and are the major structural components of chromosomes.

Aberrant histone modifications can lead to altered gene expression patterns, contributing to disease progression. The recognition of histones’ pivotal role in disease has spurred the development of …