Advances of HDAC inhibitors in tumor therapy: potential applications ...
HDAC inhibitors are considered novel epigenetic drugs whose therapeutic potential has been extensively tested in various disease models. For example, Vorinostat has shown efficacy in the …
Histone deacetylase inhibitor - Wikipedia
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally silenced …
Advancements in Hydrazide-Based HDAC Inhibitors: A Review of …
Jul 10, 2025 · This perspective will discuss recent advancements from a medicinal chemistry point of view related to the hydrazide group’s role in HDAC inhibitor development, highlighting their …
HDAC inhibitors: Targets for tumor therapy, immune modulation and …
Feb 1, 2022 · Inhibition of HDACs is a prospective therapeutic approach for reversing epigenetic alteration in several diseases. In preclinical research, numerous types of HDAC inhibitors were …
List of Histone deacetylase inhibitors - Drugs.com
Compare histone deacetylase inhibitors. View important safety information, ratings, user reviews, popularity and more.
HDAC Inhibitor: How It Works and What It Is Used For
Jul 23, 2025 · A histone deacetylase (HDAC) inhibitor is a type of medication that influences gene activity within cells. These compounds modify how DNA is packaged, affecting whether specific …
Clinical progress and functional modalities of HDAC inhibitor-based ...
Jul 13, 2025 · While HDAC Inhibitors (HDACIs) have demonstrated success in treating haematological cancers like leukemias, lymphomas, and multiple myeloma, their impact on solid tumours as …
Histone deacetylase inhibitors: molecular mechanisms of action and ...
Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell cycle …
Overview of class I HDAC modulators: Inhibitors and degraders
Oct 5, 2024 · This review provides a comprehensive overview of class I HDAC enzymes and inhibitors, by initially introducing their structure and biological roles.
Advances of HDAC inhibitors in tumor therapy: potential applications ...
Jun 27, 2025 · HDAC inhibitors are considered novel epigenetic drugs whose therapeutic potential has been extensively tested in various disease models. For example, Vorinostat has shown efficacy in …