Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

The scope of the presented studies is somewhat limited, as they primarily focus on evaluating the phenotypic changes in cardiac innervation following the loss of various Slit or Robo genes.

Anti-Aβ antibodies (Aβ-Abs) that bind specific Aβ variants are essential research tools. Furthermore, the monoclonal Aβ-Abs Aducanumab, Lecanemab, and Donanemab have recently gained approval as the ...

We’ve just announced that more than 100 funders and institutions combined continue to consider eLife papers when evaluating research contributions – regardless of our Impact Factor loss last year.