This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Just like the mechanical components in cars or computers, the molecules inside a cell can sometimes malfunction. When this happens during DNA replication, the result is an unpredictable change in the ...

This circular diagram represents the genetic code, showing how the four nucleotide bases of RNA (adenine [A], cytosine [C], guanine [G], and uracil [U]) form codons that specify amino acids. Each ...

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of ...

Structural disorder is vital for proteins' function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence.

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to ...