Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study highlights novel genotype-driven ...

NF2 deficiency eliminates LATS-mediated phosphorylation of YAP, allowing dephosphorylated YAP to enter the nucleus and co-activate CAD and DHODH transcription. Together, these enzymes accelerate de ...

The synthesis of fused imidazo[1,2-a]pyrimidines via A3 coupling reactions is a remarkable advancement in one-pot multicomponent reactions (MCRs). The A3 coupling process, which integrates an aldehyde ...

Colorectal cancer (CRC) remains one of the most prevalent and deadly cancers worldwide, with rising incidence linked to dietary and lifestyle changes. Despite advances in surgery and chemotherapy, ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves of emerging variants despite effective vaccinations, ...

Cancer cells resist chemotherapy in low-glucose environments by conserving pyrimidine nucleotides, reducing drug effectiveness and blocking cell death. A study uncovers how cancer cells adapt to ...

Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows. While chemotherapies successfully treat cancers and extend ...

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers.

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. The manuscript by Mullen et al. investigated the gene ...

Chemotherapy resistance is a major obstacle to treat nasopharyngeal carcinoma (NPC), and strategies to overcome this resistance are required. Using proteomic analysis, we found that NPC patients ...