Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

Histamine is widely known for its role in allergic reactions but also functions as a key neurotransmitter in the brain, where ...

New data show cancer survival has reached a record high — nearly 70% of patients now live at least five years after diagnosis ...

A genomic atlas of Nematostella vectensis reveals how primitive animals created multiple cell types millions of years ago, ...

In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

Explore how peptide drugs are changing the hundred-billion-level weight loss market, and how this landscape is changing as ...

Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in ...

Two proteins found on the surface of motor neurons in the brain may be essential in the progression of Parkinson's disease, ...

PEGASUS generates permeable macrocyclic peptides, offering new promise for a modality that can combine the properties of a biologic in a pill ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Abstract: This study presents an end-to-end deep learning framework for protein–to-metal-ion binding prediction, a critical task in understanding protein function, structural stability, and metal ...

Figure 1. This figure depicts the four categories of protein druggability target screening tools discussed in this section, which include structure-based methods, sequence-based methods, machine ...