The authors identify the Bearded-type small protein E(spl)m4 as a physical and genetic interactor of TRAF4 in the Drosophila wing disc. These valuable findings with potential biomedical relevance are, ...

Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a major infectious disease worldwide. Despite the availability of anti-TB drugs, the emergence of drug resistance, the ...

ABSTRACT: This study presents a comprehensive molecular characterization of lactate dehydrogenase (LDH) family members in cervical squamous cell carcinoma (CESC). Through integrated multi-omics ...

Background: Hypertrophic cardiomyopathy (HCM) lacks targeted pharmacotherapy. We employed RNA-seq of human HCM myocardium combined with Connectivity Map screening to identify repurposable drugs ...

1 Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand 2 Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut ...

A critical factor in cancer recurrence and the emergence of drug-resistant mutations is the existence of tolerant cells, such as persisters (10−14) which transiently adopt a slow-growing and highly ...

The authors implement a valuable multi-tissue approach to dissect the physiologic consequences of JNK inhibition in parallel with dietary perturbation via sucrose. The conclusions of disrupted liver, ...

Liver metastasis remains the predominant cause of mortality in patients with colorectal cancer (CRC). Nevertheless, the mechanisms underlying the initiation of colorectal cancer liver metastasis ...

A recent report in Gastrointestinal and Liver Physiology presents the effect of a functional food called active hexose correlated compound (AHCC) on liver fibrosis. A Japanese firm, Amino Up Co., Ltd.

The mouse model of Ang II–induced aneurysm formation has been previously described. 14 Ang II was infused via the use of ALZET model 2004 osmotic pumps (ALZA Corp) at 1000 ng/kg per minute. After 4 ...