Haemoglobin is a paradigm for exploring allosteric regulation, wherein ligand binding at one site induces conformational changes that affect functional activity at a distant site. These structural ...
The shikimate pathway is fundamental for the biosynthesis of aromatic amino acids—tryptophan, tyrosine and phenylalanine—in plants, bacteria and fungi. This pathway, which is absent in mammals, has ...
A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs) ...
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