The 49ers and Eagles have a rough recent history, from the Niners’ 31-7 blowout loss in the 2022 NFC Championship Game to turning the tables with a dominant 42-19 victory in the 2023 regular season. That 2023 game was the one that put Brock Purdy firmly on the map as a serious quarterback.

SportsLine's model reveals its Philadelphia Eagles vs. San Francisco 49ers best bets for Sunday's Wild Card matchup

The 49ers are dealing with a rash of injuries, while the Eagles have been inconsistent on offense despite deep talent.

NFC playoff game scenarios for Seahawks, Bears, Eagles, Rams, 49ers after Panthers, Packers losses in wild-card postseason round. What are matchups?

San Francisco 49ers visit the Philadelphia Eagles. The 49ers had a chance at the No. 1 seed in the conference but lost to the Seahawks in Week 18 and are now the No. 6 seed. The Eagles, who are defending Super Bowl champions,

The San Francisco 49ers and Philadelphia Eagles meet Sunday in an NFC Wild Card game in Philadelphia, Pennsylvania. Kickoff is set for 4:30 p.m. ET.

At linebacker, the 49ers are especially depleted. And while the Eagles’ offense isn’t nearly as dangerous as it was during their Super Bowl run, it still presents a tough test with reigning Super Bowl MVP Jalen Hurts leading the unit.