Please provide your email address to receive an email when new articles are posted on . In this Healio Video Perspective from the Retina Society meeting, Sumit Sharma, MD, of Cole Eye Institute ...

The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Cancers in the Tasmanian devil uniquely evolved into transmissible malignancies yet their underlying signalling dependencies remain unclear. This study uncovers differential kinase signalling and ...

Ianalumab targets the B-cell activating factor receptor (BAFR) and ibrutinib belongs to a class of therapeutics called Bruton ...

In nine patients with chronic lymphocytic leukemia that responded to the noncovalent BTK inhibitor pirtobrutinib and then developed resistance, analysis revealed a number of new mutations in the BTK ...

They review common resistance mechanisms, such as secondary mutations (T790M, C797S), pathway activation, and histologic transformation, emphasizing how tumor heterogeneity complicates durable ...

Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the Western Hemisphere, affecting approximately ...

While anti-VEGF therapies remain the current standard of care, many DME patients experience suboptimal responses due to non-VEGF-related disease mechanisms.