Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...

Hundreds of protein-ligand interactions have been identified through a collaboration between the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Pfizer. Georg ...

Proteins perform their many different functions via physical interactions with other molecules, in particular, small molecules present in cells, such as metabolites. These interactions occur on ...

Protein interactions are central to a diverse array of biological processes, but these are typically highly complex and involve the binding of multivalent ligands to several binding sites. It can, ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

Researchers found a rare example of an ancient protein that can still function in a molecular mirror world – offering new clues about the evolutionary history of proteins that bind to nucleic acids.

Binding proteins selectively lock on to metabolites produced by harmful microbes in the gut and prevent them from crossing ...

Targeted protein degradation is a therapeutic strategy that utilizes the cell’s natural machinery to eliminate disease-causing proteins. The field traces its origins to the development of thalidomide ...