Membrane proteins constitute a significant fraction of cellular proteomes and play indispensable roles in signalling, transport, and metabolism. Their folding and subsequent stability are not only ...

Repeat proteins, defined by sequential arrays of short structural motifs, offer an intriguing departure from the folding behaviour of conventional globular proteins. Their modular architecture enables ...

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...

Proteins are life's molecular workhorses, doing everything from turning sunlight into food to fighting viruses. They are built from 20 different types of amino acid molecules, so even a small protein ...

Hebert (center) and lead author, Guay (3 rd from left) with members of Hebert’s research group. From left, Haiping Ke, Robert Williams, Guay, Hebert, Liza Pobezinskaya, Gracie George and Wen-chuan ...

Prefoldin 5 stabilises neuronal microtubules and suppresses Tau-mediated neurotoxicity, offering a potential therapeutic target for tauopathies.

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers used ...

New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding. Proteins must ...

Collaboration delivered a successful solution for the most complex known protein folding problem ever executed on a quantum computer KARLSRUHE, Germany & COLLEGE PARK, Md.--(BUSINESS WIRE)-- Kipu ...

Researchers create Disobind, an AI tool predicting protein interactions, advancing disease biology and drug design applications.

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes ...