The hepatocyte is a main contributor to liver functions, including in metabolic homeostasis, synthesis, storage, distribution, and detoxification of xenobiotic compounds. Hepatocyte polyploidization ...

Polyploidization is observed in all mammalian species and is a characteristic feature of hepatocytes, but its molecular mechanism and biological significance are unknown. Hepatocyte polyploidization ...

This is a preview. Log in through your library . Abstract Somatic polyploidization is recognized as a means to increase gene expression levels in highly active metabolic cells. The most common ...

This is a preview. Log in through your library . Abstract Allopolyploidization, resulting in divergent genomes in the same cell, is believed to trigger a “genome shock”, leading to broad genetic and ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their ...

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its ...

Polyploidization, the combination and duplication of genomes, is a major driver of plant evolution and diversification. Yet this process causes "genome shock," leading to rapid activation of ...