Because the effect of mannitol is dose dependent, "with higher doses (1 g/kg) providing more sustained control of ICP," the authors point out that a bolus infusion is far more effective in lowering ...

Hyperosmolar therapies have evolved over the decades, with glycerol, mannitol and various concentrations of saline solutions predominating in clinical care. The mechanism of action of these agents on ...

Intracranial hypertension (ICH) is an unfortunate consequence of severe head injuries. As explained by the Monro-Kellie hypothesis, the skull is a fixed volume containing blood, cerebrospinal fluid ...

CHARLOTTESVILLE, VA (JUNE 16, 2015). Researchers in Alberta, Canada, investigated the use of the drug mannitol before and during transportation of patients with intracranial emergencies from ...