The Scientist

Locking Down Locked Nucleic Acids

Boulder, Colo.-based Proligo, under license from Danish biotech firm Exiqon, is now marketing a novel class of nucleic acid analogs called locked nucleic acids (LNA™). Sporting increased thermal ...
News Medical

Locked Nucleic Acid (LNA) Probes for qPCR

Improve assay sensitivity and specificity with Locked Nucleic Acid oligonucleotides (LNA oligos) from LGC Biosearch Technologies. LNAs are RNA bases in which the ribose is “locked” with a methylene ...
Nature

Locked Nucleic Acid-Enhanced Entropy-Driven Amplifier Combined with Catalytic Hybridization Reaction-Based DNA Circuit for Dual Amplified Detection of Single Nucleotide ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
Hosted on MSN

Lipid nanoparticles enable targeted RNA therapy for inflammatory bowel diseases

Researchers at Tel Aviv University have developed a new approach for using locked nucleic acids (LNAs)—a particularly stable type of RNA—to treat inflammatory bowel diseases such as Crohn's disease ...
ascopubs.org

First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant ...

Detecting lower in addition to the highest Gleason score prostate cancer on core biopsy and the risk of prostate cancer-specific mortality. Open-label, multicenter study of sipuleucel-T in men with ...