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Molecular bumpers and glues rewire GPCR signaling for next-generation medicines
New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Sermorelin is a synthetic peptide analog of growth hormone‑releasing hormone (GHRH), comprising the first 29 amino acids of the endogenous molecule. Studies suggest that it precisely binds to GHRH ...
The peptide known as Fragment 176-191 (also sometimes linked with AOD-9604 in its analog forms) is a truncated portion of ...
Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a ...
Nat Clin Pract Endocrinol Metab. 2006;2(4):220-230. Thyroid-hormone receptors (TRs) that bind DNA regulatory elements mediate thyroid hormone regulation. TRα mRNA mis-sense mutations, and an ...
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