Within the bustling metropolis of your cells, amidst the teeming throngs of proteins, reside the E3 ligases – the silent guardians of cellular order. These are not your average bouncers, but the ...

An illustration of Lynn McGregor. Credit: Courtesy of Lynn McGregor (McGregor); Novartis (E3 ligase); RCSB PDB (KRAS); Courtesy of Colin Garvie (protein gels) If I weren’t a chemist, I’d be: A ...

Rather than neutralize disease-causing proteins by deploying small-molecule inhibitors, some developers would destroy protein targets by ushering them to the proteasome, the cell’s garbage disposal ...

Outrun Therapeutics has launched with $10 million in seed financing. The company spun out of Satpal Virdee’s lab at the University of Dundee and is focused on stabilizing proteins, or keeping ...

Molecular glues are small, monovalent molecules that reshape an E3 ubiquitin ligase (E3) surface to promote a new protein-protein interaction with a target, triggering ubiquitination and removal by ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...