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Study provides scaffold to selectively target drug breakdown process

Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration (FDA)-approved drugs, reducing their effectiveness. However, how to prevent CYPs from ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...
MedPage Today

Dangers to Consider in Patients Who Take Docetaxel

—A long-overdue study from Japan focused on the docetaxel-associated development of febrile neutropenia in cancer patients and its association with concomitant polypharmacy involving CYP3A4 inhibitors ...
Science Daily

Study provides scaffold to selectively target drug breakdown process

Scientists explored selectively blocking the CYP3A4 protein responsible for breaking down large swaths of approved drugs, providing a way to improve drug efficacy. Scientists at St. Jude Children's ...