A physiologically based pharmacokinetic (PBPK) model developed for suraxavir marboxil (GP681) and its active metabolite GP1707D07 quantitatively predicts clinically relevant drug–drug interactions ...

Please provide your email address to receive an email when new articles are posted on . The role and status of cannabis in the United States have evolved both medically and legally. In 2020, 49.6 ...

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Summarized are OATP1B1 drug substrates showing an increase in maximal plasma concentration (C max) and AUC due to interaction with the respective inhibitor (gemfibrozil, ciclosporin or rifampin).

Cytochrome P450 1B1 (CYP1B1) has emerged as a critical enzyme in cancer pathophysiology due to its dual role in both xenobiotic metabolism and endogenous hormone regulation. Over-expression of CYP1B1 ...

Nanjing Mingde New Drug Research Co. Ltd. has identified cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the treatment of hypertension.