In a recent study posted to the bioRxiv* pre-print server, researchers investigated allosteric binders of angiotensin-converting enzyme 2 (ACE2) that significantly inhibit severe acute respiratory ...

Cooperative binding processes are widespread in Nature and are important for regulation of key enzymes and receptors. In general, cooperativity is controlled by an allosteric response to ligand ...

A team of scientists, led by Dr Steven West at the University of Exeter’s Living Systems Institute, have revealed a fresh insight into how genes are copied. The human genome - or the entire set of DNA ...

This is a preview. Log in through your library . Abstract Plasmalemma influx isotherms for K+ were measured in the system I concentration range (0.01-0.32 mM), for barley (Hordeum vulgare L.) roots of ...

Chemistry professors used the Google algorithm PageRank to identify key amino acids in the regulation of a bacterial enzyme essential for most microorganisms. Yale scientists have taken a novel ...

This new article publication from Acta Pharmaceutica Sinica B, discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a ...

Membrane-associated proteins play a vital role in a variety of cellular processes, yet little is known about the membrane-association mechanism. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) is ...

HotSpot Therapeutics is debuting with $45 million from Atlas Venture and Sofinnova Partners to explore allosteric inhibitors against tough-to-drug targets. The Cambridge, Mass.-based biotech firm will ...