Everything you need to know about the NFL match between San Francisco 49ers and Los Angeles Rams, as well as kick-off time and team news

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

Despite their records, the Cardinals have a better point differential than the 49ers. Arizona has scored 180 and allowed 171, while San Francisco has scored 194 and allowed 188. The 49ers have played in one more game though so here’s how that breaks down:

Asante Samuel Jr.'s schedule is starting to look like a draft prospect's itinerary of "30" visits. After the former Chargers

Week 9 vs. Giants with three full practices and media sessions featuring Kyle Shanahan, Robert Saleh, and Klay Kubiak.

If the Los Angeles Rams lose to the San Francisco 49ers in Week 10, it won’t matter if they have almost the same record and eight games left on the schedule. If the Rams lose, their 0-2 division and 1-3 conference records will look like chump change next to 4-0 and 7-1 on San Francisco’s end.

We know the 49ers have been calling teams about potential trades for pass rushers. They practically have no choice.