The Boston Red Sox (30-35) and New York Yankees (39-23) play the second game of their 3-game series Saturday. First pitch from Yankee Stadium is set for 7:35 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Red Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

2) Red Sox starter Walker Buehler gave up five runs on five hits (two homers) and one walk in a disastrous first inning. He pitched just 2 innings and allowed seven runs (five earned runs), seven hits and two walks while striking out two. He also hit a batter to force in a run with the bases loaded. His ERA jumped to 5.18 ERA.

After being hammered 7-0 to start off their rivalry game vs. the Yankees, the Red Sox's pitching woes hit a brutal low for the 2025 MLB season