Chiefs QB Patrick Mahomes set an NFL record during Kansas City's overtime win against the Indianapolis Colts in Week 12.

Highlights from the Week 12 matchup between the Indianapolis Colts and the Kansas City Chiefs during the 2025 NFL season.

Patrick Mahomes threw for a season-high 352 yards, Kareem Hunt ran for 104 yards and a touchdown, and Harrison Butker’s fifth field goal of the game gave the Kansas City Chiefs a come-from-behind 23-20 overtime victory over the Indianapolis Colts.

You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

The Kansas City Chiefs are living on the edge this season. Their playoff hopes were flickering late in the early window of games. The Indianapolis Colts had them on the verge of a huge home loss that would have knocked them below .500 and been a massive blow to their playoff hopes. But the Chiefs remembered how to win in close games.

The Indianapolis Colts announced they have officially activated cornerback Charvarius Ward Sr. from injured reserve after the starter missed four games due to a concussion. The team also announced that they have waived cornerback Cameron Mitchell.

An Indianapolis Colts insider has shut down some rather alarming Daniel Jones news that surfaced before Week 12.